Role of lubricin and boundary lubrication in the | GBS Bearing

Transcription, Translation, and Function of Lubricin, a .

Lubricin plays a critical role as a boundary lubricant in articulating joints. 1-4 This amphiphilic glycoprotein, which is also called superficial zone protein, ... Boundary lubrication may also be dominant at the cornea–contact lens interface where there is a relative lack of aqueous tear.

Friction force microscopy of lubricin and hyaluronic acid between hydrophobic and hydrophilic surfac

Friction force microscopy of lubricin and hyaluronic acid between hydrophobic and hydrophilic surfaces ... a mixture the two to further understand the role of lubricin in boundary lubrication and to examine the hypotheses that lubri-cin and HA, alone or in ...

Lubricin: New Promise for Joint-Preserving Therapy | Rheumatology Netwo

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis. Proc Natl Acad Sci (2013) 110:5852-5857 23. Waller KA, Zhang LX, Fleming BC, Jay GD. Preventing friction-induced chondrocyte apoptosis: comparison of human synovial fluid ...

Regulation of lubricin for functional cartilage tissue regeneration: a review | SpringerLi

Background Lubricin is chondrocyte-secreted glycoprotein that primarily conducts boundary lubrication between joint surfaces. Besides its cytoprotective function and extracellular matrix (ECM)... ... Structure and functional role of lubricin Lubricin, a product of the ...

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis | PN

These results demonstrate a direct connection between lubricin, boundary lubrication, and cell survival and suggest that supplementation of synovial fluid with lubricin may be an effective treatment to prevent cartilage deterioration in patients with genetic or ...

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptos

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis Kimberly A. Wallera, Ling X. Zhangb, Khaled A. Elsaidc, Braden C. Fleminga,d,e, Matthew L. Warmanf,g, and Gregory D. Jaya,b,h,1 aCenter for Biomedical Engineering and the ...

Regulation of lubricin for functional cartilage tissue regeneration: a review | Biomaterials Research | Full Te

The fundamental role of lubricin is lubrication of boundary surface of cartilage []. Hence, transmutation of lubricin metabolism would conspicuously influence joint performance. In fact, patients who suffer from osteoarthritis (OA), degenerative joint disease, or ...

Galectin-3 Binds to Lubricin and Reinforces the .

Effective boundary lubrication by lubricin is dependent upon both its ability to adsorb to articular cartilage 11,12 and the presence of O-linked β(1–3)Gal-GalNAc oligosaccharides 13; however ...

Molecular synergy in biolubrication: The role of cartilage oligomeric matrix protein (COMP) in surface-structuring of lubricin - ScienceDire

Molecular synergy in biolubrication: The role of cartilage oligomeric matrix protein (COMP) in surface-structuring of lubricin ... B.C. Fleming, M.L. Warman, G.D. JayRole of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis Proc. Natl ...

The role of lubricin in normal and pathological joint tissue: A contemporary review.OA Anato

The role of lubricin in normal and pathological joint tissue: a contemporary review G Musumeci 1* Authors affiliations (1) ... It has been shown that lubricin is critical to normal joint function, providing boundary lubrication of congruent articular surfaces under ...

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptos

These results demonstrate a direct connection between lubricin, boundary lubrication, and cell survival and suggest that supplementation of synovial fluid with lubricin may be an effective treatment to prevent cartilage deterioration in patients with genetic or ...

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis | Kimberly A Waller | Request P

Request PDF on ResearchGate | Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis | Osteoarthritis is a complex disease involving the mechanical breakdown of articular cartilage in the presence of altered joint mechanics and ...

Regulation of lubricin for functional cartilage tissue .

lubricin is verified to carry its responsibility for antag-onizing abnormal cellular adhesion and overgrowth. The fundamental role of lubricin is lubrication of boundary surface of cartilage [18]. Hence, transmuta-tion of lubricin metabolism would conspicuously influ-ence joint performance. In fact, patients who suffer

Friction force microscopy of lubricin and hyaluronic acid .

Lubricin and hyaluronic acid (HA) are two constituents of synovial fluid thought to have a role in boundary lubrication. Boundary lubrication3 is accomplished by lubricants adsorbed or bonded to the apposing bearing surfaces and is operative where surfaces come into contact.4 It is one of the multiple

Anti-Inflammatory Role of Lubricin/Proteoglycan 4 (PRG4 .

Background/Purpose: Lubricin/proteoglycan-4 (PRG4) is a mucinous glycoprotein secreted by synovial fibroblast and superficial zone chondrocyte. PRG4 has a homeostatic multifaceted role in the joint including boundary lubrication, friction lowering of apposed cartilage surfaces and prevention of synovial overgrowth.

The role of lubricin in the mechanical behavior of synovial flui

The role of lubricin in the mechanical behavior of synovial fluid. Jay G.D., Torres J.R., Warman M.L., ... where it contributes to boundary lubrication under load. Individuals with genetic deficiency of lubricin develop precocious joint failure. The role of lubricin in We ...

Lubricin: New Promise for Joint-Preserving Therapy .

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis. Proc Natl Acad Sci (2013) 110:5852-5857 23. Waller KA, Zhang LX, Fleming BC, Jay GD. Preventing friction-induced chondrocyte apoptosis: comparison of human synovial fluid and hylan G-F 20.

The Role Of Lubricin And Galectins In Osteoarthritis And Cartilage Lubricati

The Role Of Lubricin And Galectins In Osteoarthritis And Cartilage Lubrication By Heidi Reesink Abstract ... and galectins-1 and -3 to determine if lubricin and galectins could synergistically enhance articular cartilage boundary lubrication and; 3) evaluate equine ...

Decreased lubricin concentrations and markers of joint .

The decrease in SF lubricin concentrations following ACL injury may place the joint at an increased risk of wear‐induced damage as a consequence of lack of boundary lubrication, potentially leading to secondary osteoarthritis. The decrease in SF lubricin was associated with an increase in levels of inflammatory cytokines.

Supramolecular synergy in the boundary lubrication of .

Our results point to a scenario where hyaluronan, phosphatidylcholines and lubricin, each with a very different role, act together to provide the extreme boundary lubrication in articulating ...

Molecular mechanisms of aqueous boundary lubrication by .

The conformation of mucins and PRG4 on surfaces plays an important role in boundary lubrication (see below), where the ability to form sterically repulsive, extended surface layers prevents surface interdigitation and shifts, particularly at low sliding speeds, the plane of shear away from the rubbing surfaces into the mucin layer. 4.